Christine N. Sang

Christine N. Sang, MD, MPH

Director & Principal Investigator

Translational Pain Research

Professional Activities

Dr Christine N. Sang received her MD at the Johns Hopkins University School of Medicine, and Master of Public Health at Harvard University. She served as Associate Medical Director of the Pain Research Clinic at the NIH/Clinical Center (National Institute of Dental and Craniofacial Research), and Director of the Clinical Trials Program at the MGH Pain Center, Massachusetts General Hospital, she directs the Translational Pain Research Program at the Brigham and Women's Hospital. Dr Sang has served on numerous national and international steering committees and scientific advisory boards for professional societies and pharmaceutical companies, and has both participated in and organized consensus conferences in neuropathic pain, neurofibromatosis, and spinal cord injury. She speaks nationally and internationally on the clinical development of novel analgesics, clinical trial design, and pain management of central and peripheral neuropathic pain syndromes. Her own clinical lab, funded by the National Institutes of Health, Paralyzed Veterans of America, Christopher Reeve Paralysis Foundation, and other competitive funding sources, systematically evaluates novel potential analgesics to target selective mechanisms of pain.

Select Recent Publications

  • Sang CN, Gracely RH, Max MB, Bennett GJ. “Capsaicin-evoked mechanical allodynia and hyperalgesia cross nerve territories: Evidence for a central mechanism.” Anesthesiology 1996; 85:491-6.
  • Coghill RC, Sang CN, Berman K, Iadarola M. “Global cerebral blood flow decreases during pain.” J Cereb Blood Flow 1998; 18:141-7.
  • Sang CN, Hostetter W, Gracely RK Chappell AS, Schoepp DD, Lee G, Whitcup S, Caruso R, Max “MB.AMPA/kainate antagonist LY293558 reduces capsaicin-evoked hyperalgesia but not pain in normal skin in humans.” Anesthesiology 1998; 89:1060-7.
  • Dionne RA, Max MB, Gordon S, Parada S, Sang CN, Gracely RK Sethna NF, McLean DB. “The substance P receptor antagonist CP-99,994 reduces acute postoperative pain.” Clin Pharm Ther, 1998; 64(5):562-8.
  • Sang CN. “Advances in neuropathic pain: Glutamate receptor antagonists. Managing pain in the neurologic patient”, Neurol Rev Suppl, 1998, p.5.
  • Sang CN, Max MB, “Gracely RH. Stability and reliability of detection thresholds for human A-Beta and A-delta sensory afferents determined by cutaneous electrical stimulation.” J Pain Symptom Manage. 2003; 25(1):64-73.
  • Coghill RC, Sang CN, Maisog JK ladarola MJ. “Pain intensity processing within the human brain: a bilateral, distributed mechanism.” J Neurophysiol 1999; 82(4):1934-3.
  • Gilron I, Max MB, Lee G, Booher SL, Sang CN, “Chappell AS, Dionne RA Effects of the AMPA/kainate antagonist LY293558 on spontaneous and evoked postoperative pain.” Clin Pharmacol Ther. 2000; 68(3):320-7.
  • Sang CN. “NMDA receptor antagonists in neuropathic pain: Experimental methods to clinical trials.” J Pain Symptom Management 2000; 19 (1 Suppl): S21-5.
  • Sang CN, Booher SL, Gilron I, Parada S, Max MB. “Low affinity NMDA receptor antagonists in dabetic neuropathy and postherpetic neuralgia: A two-stage placebo-controlled efficacy and dose-response trial of dextromethorphan and memantine.” Anesthes, 2002; 96(5):1053-61.
  • Stojanovic W, Vu TN, Caneris OA, Slezak J, Cohen SP, Sang CN. “The role of fluoroscopy in cervical epidural steroid injections: An analysis of contrast dispersal patterns.” Spine 2002; 27(5):509-14.
  • Cluff R, Mehio AK, Cohen SP, Chang Y, Sang CN, Stojanovic W. “The technical aspects of epidural steroid injections: A national survey.” Anesth Analg 2002; 95(2):403-8.
  • Gordon SM, Brahim JS, Dubner R, McCullagh LK, Sang CN, Dionne RA. “Attenuation of hyperalgesia in a randomized trial by suppression of pain in the immediate postoperative period.” Anesth Analg. 2002; 95(5):1351-7.
  • Sang CN, Ramadan NK Wallihan R, et al. “LY293558, a novel AMPA/GluR5 antagonist, is efficacious and well-tolerated in acute migraine.” Cephalalgia 2004; 249(7):596-602.
  • MacCollin M, Chiocca A, Evans DG, Friedman JM, Horvitz R, Jaramillo D, Lev M, Mautner VF, Niimura M, Plotkin SR, Sang CN, Stemmer-Rachamimov A, Roach ES. “Diagnostic Criteria for Schwannomatosis.” Neurol. 2005;64(11):1838-45.
  • Black D and Sang CN. “Advances and limitations in the evaluation of analgesic combination therapy.” Neurol. 2005; 65(12 Suppl 4):S3-6.
  • Kajdasz DK, Iyengar S, Desaiah D, Backonja MM, Farrar JT, Fishbain DA, Jensen TS, Rowbotham MC, Sang CN, Ziegler D, McQuay HJ. “Duloxetine for the management of diabetic peripheral neuropathic pain: evidence-based findings from post hoc analysis of three multicenter, randomized, double-blind, placebo-controlled, parallel-group studies.” Clin Ther 2007; 2536-46.
  • Chizh BA, Sang CN. “Use of Sensory Methods for Detecting Target Engagement in Clinical Trials of New Analgesics.” Neurotherapeutics 6(4): 749-754, 2009.
  • Sang CN and Bennett GJ. “Novel Therapies for the Control and Prevention of Neuropathic Pain.” Neurotherapeutics 6(4):607-608, 2009.
  • Benzon HT, Connis RT, De Leon-Casasola OA, Glass DD, Korevaar WC, Cynwyd B, Mekhail NA, Merrill DG, Nickinovich DG, Rathmell JP, Sang CN, Simon DL. “Practice guidelines for chronic pain management: an updated report by the American Society of Anesthesiologists Task Force on Chronic Pain Management and the American Society of Regional Anesthesia and Pain Medicine. American Society of Anesthesiologists Task Force on Chronic Pain Management; American Society of Regional Anesthesia and Pain Medicine.” Anesthesiology. 112(4):810-33, 2010.
  • Sang CN, Sathyanarayana R, and Sweeney M. “Gastroretentive gabapentin formulation reduces intensity of pain associated with postherpetic neuralgia: A Phase III clinical trial.” Clin J Pain, 2012 Jul 13.
  • Sang, CN and Benavides, R. “Central neuropathic pain following spinal cord injury. In: Warfield C, Bajwa Z, and Wootton RJ, eds. Principles and Practice of Pain Medicine”, 3rd Edition. McGraw-Hill, New York, NY, 2014.