Laboratory of Nanomedicine and Biomaterials

Select Recent Publications

  • Salvador-Morales C, Valencia PM, Gao W, Karnik R, Farokhzad OC. Spontaneous Formation of Heterogeneous Patches on Polymer-Lipid Core-Shell Particle Surfaces during Self-Assembly. Small, 2012 Oct 26. doi: 10.1002/smll.201201499.
  • Zhao W, Cui CH, Bose S, Guo D, Shen C, Wong WP, Halvorsen K, Farokhzad OC, Teo GS, Phillips JA, Dorfman DM, Karnik R, Karp JM. Bioinspired multivalent DNA network for capture and release of cells. Proc Natl Acad Sci U S A, 2012 Nov 27;109(48):19626-31.
  • Xiao Z, Ji C, Shi J, Pridgen EM, Frieder J, Wu J, Farokhzad OC. DNA Self-Assembly of Targeted Near-Infrared-Responsive Gold Nanoparticles for Cancer Thermo-Chemotherapy. Angew Chem Int Ed Engl, 2012 Oct 18. doi: 10.1002/anie.201204018.
  • Valencia PM, Pridgen EM, Perea B, Gadde S, Sweeney C, Kantoff PW, Bander NH, Lippard SJ, Langer R, Karnik R, Farokhzad OC. Synergistic cytotoxicity of irinotecan and cisplatin in dual-drug targeted polymeric nanoparticles. Nanomedicine (Lond), 2012 Oct 17.
  • FarokhzadOC. Using ligands to target cancer cells. Clin Adv Hematol Oncol, 8(2012) 543-4.
  • Valencia PM, Farokhzad OC, Karnik R, Langer R. Microfluidic technologies for accelerating the clinical translation of nanoparticles. Nat Nanotechnology, 7(2012) 623-9.
  • Zhang XQ, Xu X, Bertrand N, Pridgen E, Swami A, Farokhzad OC. Interactions of nanomaterials and biological systems: Implications to personalized nanomedicine. Advanced Drug Delivery Reviews, 64(2012) 1363-84.
  • Kim Y, Chung BL, Ma M, Mulder WJ, Fayad ZA, Farokhzad OC, Langer R. Mass Production and Size Control of Lipid-Polymer Hybrid Nanoparticles through Controlled Microvortices. Nano Letters, 12(2012) 3587-94.
  • Graf N, Bielenberg DR, Kolishetti N, Muus C, Banyard J, Farokhzad OC, Lippard SJ. a(V)ß(3) Integrin-Targeted PLGA-PEG Nanoparticles for Enhanced Anti-tumor Efficacy of a Pt(IV) Prodrug. ACS Nano, 6(2012) 4530-9.
  • Xiao Z, Farokhzad OC. Aptamer-functionalized nanoparticles for medical applications: challenges and opportunities. ACS Nano, 6(2012) 3670-6.
  • Mieszawska AJ, Gianella A, Cormode DP, Zhao Y, Meijerink A, Langer R, Farokhzad OC, Fayad ZA, Mulder WJ. Engineering of lipid-coated PLGA nanoparticles with a tunable payload of diagnostically active nanocrystals for medical imaging. Chem Commun, 48(2012) 5835-7.
  • Hrkach J, Von Hoff D, Ali MM, Andrianova E, Auer J, Campbell T, De Witt D, Figa M, Figueiredo M, Horhota A, Low S, McDonnell K, Peeke E, Retnarajan B, Sabnis A, Schnipper E, Song JJ, Song YH, Summa J, Tompsett D, Troiano G, Van Geen Hoven T, Wright J, Lorusso P, Kantoff PW, Bander NH, Sweeney C, Farokhzad OC, Langer R, Zale S. Preclinical Development and Clinical Translation of a PSMA-Targeted Docetaxel Nanoparticle with a Differentiated Pharmacological Profile. Science Translational Medicine, 4(2012) 128ra39.
  • Radovic-Moreno AF, Lu TK, Puscasu VA, Yoon CJ, Langer R, Farokhzad OC. Surface Charge-Switching Polymeric Nanoparticles for Bacterial Cell Wall-Targeted Delivery of Antibiotics. ACS Nano, 6(2012) 4279-87.
  • Kamaly N, Xiao Z, Valencia PM, Radovic-Moreno AF and Farokhzad OC. Targeted polymeric therapeutic nanoparticles: design, development and clinical translation. Chemical Society Reviews, 41 (2012) 2971.
  • Xiao Z, Levy-Nissenbaum E, Alexis F, Lupták A, Teply BA, Chan JM, Shi J, Digga E, Cheng J, Langer R and Farokhzad OC. Engineering of targeted nanoparticles for cancer therapy using internalizing aptamers isolated by cell-uptake selection. ACS Nano, 6 (2012) 696.
  • Chan JM, Rhee JW, Drum CL, Bronson RT, Golomb G, Langer R and Farokhzad OC. In vivo prevention of arterial restenosis with paclitaxel-encapsulated targeted lipid-polymeric nanoparticles. Proc Natl Acad Sci U S A, 108 (2012) 19347.
  • Wang AZ, Langer R and Farokhzad OC. Nanoparticle delivery of cancer drugs. Annual Reviews of Medicine, 63 (2012) 185.
  • Shi J, Xiao Z, Kamaly N and Farokhzad OC. Self-assembled targeted nanoparticles: evolution of technologies and bench to bedside translation. Accounts of Chemical Research, 44 (2011) 1123.
  • Valencia PM, Hanewich-Hollatz MH, Gao W, Karim F, Langer R, Karnik R and Farokhzad OC. Effects of ligands with different water solubilities on self-assembly and properties of targeted nanoparticles. Biomaterials, 32 (2011) 6226.
  • Rhee M, Valencia PM, Rodriguez MI, Langer R, Farokhzad OC and Karnik R. Synthesis of Size-Tunable Polymeric Nanoparticles Enabled by 3D Hydrodynamic Flow Focusing in Single-Layer Microchannels. Advanced Materials, 23 (2011) H79.
  • Timko BP, Whitehead K, Gao W, Kohane DS, Farokhzad OC, Anderson D, and Langer R. Advances in Drug Delivery*. Annual Review of Materials Research, 41 (2011) 1.
  • Shi JJ, Xiao ZY, Votruba AR, Vilos C and Farokhzad OC. Differentially Charged Hollow Core/Shell Lipid-Polymer-Lipid Hybrid Nanoparticles for Small Interfering RNA Delivery. Angewandte Chemie International Edition, 50 (2011) 7027.
  • Gao W and Farokhzad OC. Self-Propelled Microrockets to Capture and Isolate Circulating Tumor Cells (Perspective). Angewandte Chemie International Edition, 50 (2011) 7220.
  • Dhar S, Kolishetti N, Lippard SJ and Farokhzad OC Targeted delivery of a cisplatin prodrug for safer and more effective prostate cancer therapy in vivo. Proc Natl Acad Sci U S A, 108 (2011) 1850.