CENTER FOR PERIOPERATIVE GENOMICS

The Center for Perioperative Genomics encompasses two laboratories with numerous collaborators, dedicated to improving perioperative outcomes in cardiac surgery.

CPG investigators and staff

The Center has a three-fold mission. We are dedicated to identifying genetic and non-genetic factors that contribute to adverse perioperative outcomes, notably postoperative atrial fibrillation, myocardiac infarction, and heart failure. We are committed to identifying genetic factors contributing to bicuspid aortic valve disease, a major class of structural heart disease. Finally, the Center is working to elucidate the transcriptional response of human heart tissue to ischemia.

Principal Investigators

Simon C. Body, M.B., Ch.B., M.P.H., F.A.H.A.

Simon C Body

Dr. Simon C. Body is an Associate Professor of Anesthesia at Harvard Medical School and a cardiac anesthesiologist at Brigham and Women’s Hospital. His primary foci are the genetic etiology and molecular biology of atrial fibrillation occurring after cardiac surgery, and the genetic etiology of bicuspid aortic valve disease. (PubMed)

  • Medical School: Auckland Medical School, Auckland, New Zealand
  • Residencies: Auckland Hospital Board & Royal North Shore Hospital, Sydney, Australia
  • Fellowship: Cardiothoracic Anesthesia, Brigham and Women's Hospital, Boston, MA
  • Masters of Public Health: Harvard School of Public Health, Boston, MA

Dr. Jochen D. Muehlschlegel, M.D., M.M.Sc., F.A.H.A.

Jochen D Muehlschlegel

Dr. Jochen D. Muehlschlegel is an attending cardiovascular anesthesiologist at Brigham and Women’s Hospital, and an Assistant Professor of Anesthesia at Harvard Medical School. Dr. Muehlschlegel, additionally, is the Principal Investigator of the TRANSCRIBE study (Transcriptomic Analysis of Left Ventricular Gene Expression). He is working on numerous projects to examine the response of the human myocardium to ischemia. (PubMed)

  • Medical School: Albert Ludwigs University Freiburg, Germany
  • Residency: Shands Hospital, Gainesville, FL
  • Fellowship: Cardiac Anesthesia, Brigham and Women's Hospital, Boston, MA
  • Masters of Medical Science: Harvard Medical School, Boston, MA

Co-Investigators

Stanton K. Shernan, M.D.

Stanton K Shernan

Dr. Stanton K. Shernan is the Director of Cardiac Anesthesia at Brigham and Women’s Hospital and a Professor of Anesthesia at Harvard Medical School. His research interests include myocardial ischemia-reperfusion injury, systemic inflammation, perioperative genomics and perioperative echocardiography. (PubMed)

  • Medical School: Tufts University School of Medicine, Boston, MA
  • Residencies: Beth Israel Hospital, Boston, MA & Brigham and Women’s Hospital, Boston, MA

Martin I. Sigurdsson, M.D., Ph.D.

Martin I. Sigurdsson

Dr. Martin I. Sigurdsson is a resident in anesthesiology at Brigham and Women’s Hospital. His primary research interests are genetic variants and atrial gene expression patterns in patients who develop atrial fibrillation after cardiac surgery. He is also interested in identifying genetic variants associated with acute organ failures. (PubMed)

  • Medical School: University of Iceland (2003-2009), Reykjavik, Iceland
  • Ph.D. in Genetics: University of Iceland (2008-2011), Reykjavik, Iceland
  • Residency: Brigham and Women’s Hospital (2012-2016), Boston, MA, USA

Louis A. Saddic M.D. Ph.D.

Louis A. Saddic

Dr. Louis Saddic is a resident in anesthesiology at the Brigham and Women’s Hospital. His research interests include high throughput sequencing of mRNA and miRNA in a cardiopulmonary bypass model of cardiac ischemia. He is also interested in validation of candidate genes in animal models of ischemia. (PubMed)

  • Medical School: Stanford University School of Medicine, Stanford, CA (2005-2012)
  • Graduate School: Stanford University School of Medicine, Stanford, CA (2005-2012)
  • Internship: Brigham and Women’s Hospital Department of Internal Medicine, Boston, MA (2012-2013)
  • Residency: Brigham and Women’s Hospital Department of Anesthesiology, Boston, MA (2013-current)

Mahyar Heydarpour, M.Sc., PhD.

Mahyar Heydarpour

Dr. Mahyar Heydarpour is a statistical geneticist in anesthesiology at Brigham and Women’s Hospital and Research Associate at Harvard Medical School. His research interests are Genome Wide Association Study (GWAS) of Bicuspid Aortic valve (BAV) and Atrial Fibrillation (AF) for patients undergoing cardiac surgery. He is also interested in identifying expression quantitative trait loci (eQTL) in Human left atrium associated with AF. He is involving in numerous research projects at the Center of preoperative genomics for statistical analysis including GWAS, RNAseq, eQTL, ASE, and CNV tests. Dr. Heydarpour has been part of the team since 2013 (PubMed)

  • Ph.D. in Animal Genetics: University of Guelph (2001- 2006), Guelph, Canada
  • Assistant Professor: Ferdowsi University (2006 – 2008), Mashhad, Iran
  • Postdoc Fellow: McMaster University (2009-2011), Department of Medicine, Hamilton, Canada
  • Postdoc Fellow: University of Guelph (2011-2013), Bovine Genomics, Guelph, Canada
  • Research Associate: Brigham and Women’s Hospital (2013 – current), Boston, MA, USA

Staff

Kujtim Bodinaku

Dr. Kujtim Bodinaku, M.D., is the head data coordinator and manager of the CABG Genomics team. He holds a Doctor of Medicine from University of Tirana, Faculty of Medicine, and worked as a research associate at Wellesley Hospital in Toronto, Ontario, Canada for over three years. His previous specialty prior to his current position was gastroenterology. Dr. Bodinaku has been part of the team since 2001, and has been working at Brigham and Women's Hospital since 1992. (PubMed)

James Gosnell

James Gosnell, R.N., is the research nurse for the CABG Genomics Research Study. He holds a Bachelor of Science in Nursing from Salem State University, and has worked at Brigham and Women's Hospital for over twenty-five years (including many years of clinical work). Additionally, Mr. Gosnell enlisted into the United States Air Force during the Vietnam War, and served the nation while being stationed in North Dakota (two years) and Italy (over three years), and earned the prestigious title of lieutenant colonel.

Svetlana Gorbatov

Svetlana Gorbatov, M.P.H., is a research associate for the CABG Genomics Program. Ms. Gorbatov earned her Bachelor of Science degree in Biology at Odessa State University in Odessa, Ukraine and her Master of Public Health degree from the University of Massachusetts - Worcester, with a concentration in Epidemiology. Prior to working at Brigham and Women's Hospital, she worked for the City Department of Public Health in Odessa, Ukraine, as an epidemiologist, through investigating and treating incalculable disease-ridden populations. Ms. Gorbatov has been with the team since 2003.

Michael Francke

Michael Francke, B.S., is a clinical research assistant for the CABG Genomics Program. He holds a Bachelor of Science degree in Biochemistry from the Boston College Arts and Sciences Honors Program, and plans to attend medical school in the Fall of 2014. He currently works primarily with identifying genetic variation that is associated with bicuspid aortic valve disease.

Claudia L. Sotillo

Claudia L. Sotillo, MSIV, B.S., is a fourth-year medical student at Boston University School of Medicine and a Foundation for Anesthesia Education and Research (FAER) year-long research fellow with Dr. Jochen Muehlschlegel. Her past undergraduate and post-baccalaureate research projects include: the structural characterization of AAV6 and AAV7 capsids for gene therapy applications, the effects of hemin and Epo on erythroid progenitor cells, and DNA subcloning and vector construction for an alpha-1 antitrypsin deficiency mouse model. She recently merged her interest in genetics and global health in her current project, which involves the utilization of Next Generation Sequencing techniques to determine gene variants responsible for rheumatic heart disease susceptibility in Rwandan young adults. She will start anesthesiology residency training in 2016.

Our Collaborators

Fox Lab

Collard Lab

Seidman Lab

Channing Division of Network Medicine

contact

The Center for Perioperative Genomics can be contacted at 617-732-8127 Our mailing address is:

Brigham and Women’s Hospital Department of Anesthesiology, Thorn 724A 75 Francis St. Boston, MA 02115