Jochen D. Muehlschlegel, M.D., M.M.Sc.
My clinical work as a cardiac anesthesiologist focuses on delivering perioperative care for patients undergoing complex cardiac procedures, from coronary artery bypass grafting surgery to aortic surgery to heart transplants, using state-of-the-art technology such as three-dimensional transesophageal echocardiography.
My research, funded by the National Institutes of Health, the American Heart Association and the Harvard Catalyst, focuses on perioperative genomics, specifically on genetic variation associated with myocardial injury in cardiac surgical patients. We know that myocardial injury is common in cardiac surgical patients and directly associated with morbidity and mortality. Genome-wide association studies have identified candidate risk loci, yet the functional mechanisms of disease-causing DNA variants are unclear. RNA sequencing provides unprecedented resolution of gene expression thus allowing direct correlation of DNA variant to mRNA expression. The combination of genome-wide genotyping and RNA sequencing will identify expression quantitative trait loci, potentially identifying causative variants and responsible xbiological pathways.
We hope to define the link between genetic variation, altered expression and myocardial injury in humans, and significantly advance the biological understanding of myocardial injury. These insights may facilitate the development of novel and specific therapeutic approaches to alleviate the burden of myocardial injury in humans, which are urgently needed to improve the morbidity and mortality of this common disease.
- Masters of Medical Science: Harvard Medical School, Boston, MA
- Fellowship: Cardiac Anesthesia, Brigham and Women's Hospital, Boston, MA
- Residency: Shands Hospital, Gainesville, FL
- Medical School: Albert Ludwigs University Freiburg, Germany