Hongwei Gao

Hongwei Gao, M.D., Ph.D.

Principal Investigator

Center for Experimental Therapeutics & Reperfusion Injury – Gao Lab

Research Interest

The long-term objective of my lab is to dissect the cellular and molecular mechanisms that regulate immune and inflammatory events during lung injury and multi-organ failure in sepsis. In recent years, it has become clear that the complement system plays an important immunoregulatory role at the interface of innate and acquired immunity during inflammation. Our research uses a combination of cell biology, molecular biology, immunology, and experimental pathology to identify the function of complement, especially C5a and its receptors, in acute lung injury and pulmonary dysfunction during sepsis. We are also interested in dissecting the function of transcription factors, cytokines and their networks of interaction, which underlie the inflammatory process in airway injury. Ultimately, a more complete knowledge of the causative mechanisms in airway injury and multi-organ failure will promote the goal of devising more effective strategies for the prevention and treatment of lung diseases and sepsis.

Medical Training

  • Postdoctoral Fellow, Pathology, University of Michigan
  • Ph.D., Microbiology and Molecular Genetics, Michigan State University
  • M.D., Joint Eight-Year-Program, Nankai University and Tianjin Medical University

Select Recent Publications

  • Yan C, Ward PA, Wang X, Gao H. “Myeloid Depletion of SOCS3 Enhances LPS-Induced Acute Lung Injury through CCAAT/Enhancer Binding Protein δ Pathway.” FASEB J. 2013 Apr 12. [Epub ahead of print].
  • Yan C, Johnson PF, Tang H, Ye Y, Wu M, Gao H. “CCAAT/enhancer binding protein δ is a critical mediator of lipopolysaccharide-induced acute lung injury.” Am J Pathol. 2013; 182:420-30.
  • Yan C, Wu M, Cao J, Tang H, Zhu M, Johnson PF, Gao H. “Critical role for CCAAT/enhancer binding protein β in immune complex-induced acute lung injury.” J Immunol. 2012; 189:1480-90.
  • Yan C, Gao H. New insights for C5a and C5a receptors in sepsis. Front Immunol. 2012; 3:368.
  • Guo Q, Shen N, Yuan K, Li J, Wu H, Zeng Y, FoxIII J, Bansal AK, Singh B, Gao* H, Wu* M. “Caveolin-1 plays a critical role in host immunity against Klebsiella pneumoniae by regulating STAT5 and Akt activity.” Eur J Immunol. 2012; 42:1-13.